Hypoxemia

The hypoxemic treatment led to a decrease in SpO2 (81.7±2.6 and 81.4±2.4% in the hypoxemia and hypoxemic endotoxemia groups, respectively) and hyperventilation ...

3.5 hours of hypoxemia (FiO2±11.5%), normoxemic endotoxemia (FiO2 21%, administration of 2 ng/kg endotoxin), or hypoxemic endotoxemia (n=10 per group) were applied to 30 healthy volunteers. The hypoxemic treatment led to a decrease in SpO2 (81.7±2.6 and 81.4±2.4% in the hypoxemia and hypoxemic endotoxemia groups, respectively) and hyperventilation accompanied by a decrease in PaCO2 (0.8±0.5 and 1.5±0.6 kPa) and an increase in pH. The oxygen content of arterial blood (CaO2) fell between 20.5 and 2,9 and between 23.5 and 4.4%, respectively. Over time, lactate levels were marginally but significantly higher in both hypoxemic groups compared to the normoxemic endotoxemia group (P<0.0001 for both hypoxemic groups) but remained below 2.3 mmol/L in all participants. It was likely that the reductions in glycolysis that were brought on by hyperventilation were the cause of the slight increases in lactate that were detected. No substantial lactate rises were observed as a consequence of hypoxia, regardless of whether inflammation was present or not. For a study, researchers sought to examine whether hypoxemia and systemic inflammation raise lactate levels in healthy participants.