Biology

At the ICMRBS 2022 Conference, Bruker today announces a new 8 mm 15N TROSY Cryoprobe for enabling novel NMR functional structural biology investigatio.

[Euromar 2022](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.bruker.com%2Fen%2Fnews-and-events%2Fnews%2F2022%2Fbruker-announces-three-ghz-nmr-system-orders.html&esheet=52821440&newsitemid=20220822005139&lan=en-US&anchor=Euromar+2022&index=5&md5=dd130c7b10ae871d9d01ee3ee8e8455f), Bruker has received three orders for compact 1.0 GHz NMR systems from the [RIKEN Center for Biosystems Dynamics Research](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.bdr.riken.jp%2Fen%2Fresearch%2Flabs%2Fshimada-i%2Findex.html&esheet=52821440&newsitemid=20220822005139&lan=en-US&anchor=RIKEN+Center+for+Biosystems+Dynamics+Research&index=6&md5=e62ad237d795df4f535f2728de1237d9) in Yokohama, Japan, the Precision Medicine and Metabolism Lab at [CIC bioGUNE](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.cicbiogune.es%2Fpeople%2Fomillet&esheet=52821440&newsitemid=20220822005139&lan=en-US&anchor=CIC+bioGUNE&index=7&md5=f824e8d292a2cf875663757916590338), and the BioNMR Group at [Universitat de Barcelona](https://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fbionmr.ub.edu%2Fpeople.php&esheet=52821440&newsitemid=20220822005139&lan=en-US&anchor=Universitat+de+Barcelona&index=8&md5=4f04f2c1042436889eaf8fbe585cad09), both in Spain. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular and cell biology research, in applied and pharma applications, in microscopy and nanoanalysis, as well as in industrial applications. Guido Pintacuda, CNRS Research Director and Director of the Lyon High-field NMR Center explained: “The new Bruker 160 kHz MAS HCN probe will push structural, cellular and disease biology research into the next phase of the solid-state NMR scientific evolution. This first 1.2 GHz NMR in France will allow researchers in Lille, and from all over France, to advance their understanding of functional structural biology and advanced materials. This will notably open new avenues for the study of dynamics, hydrogen bonds, disulfide bonds and metal centers of many metalloproteins, nucleic acids and carbohydrates." [BUSINESS WIRE](https://www.businesswire.com/))--At the [ICMRBS](https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.icmrbs2022.org%2F&esheet=52821440&newsitemid=20220822005139&lan=en-US&anchor=ICMRBS&index=1&md5=235e39807d3d3e39f15114f6be88d274) 2022 Conference, Bruker today announces a new 8 mm 15N TROSY Cryoprobe for enabling novel NMR functional structural biology investigations into larger globular proteins and protein complexes. Bruker also announces the technology introduction of a novel 160 kHz Ultra-fast spinning Magic Angle Spinning (MAS) NMR probe for advancements in solid-state membrane protein, prion, and aggregates research. Haribabu (‘Hari’) Arthanari, Associate Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and in the Department of Cancer Biology at the Dana-Farber Cancer Institute, stated: “We can now greatly expand the scientific scope of functional structural biology by high-field NMR with 15N-detected experiments to study non-deuterated protein systems, like disordered proteins or globular proteins, which can now be made in flexible eukaryotic expression systems. Professor Jean-Pierre Simorre, Research Director, and Deputy Director INC at CNRS, commented: “We are thrilled to have received our 1.2 GHz NMR system. The significantly increased new capabilities of this 160 kHz 0.4mm MAS probe at high NMR fields may enable novel insights and discoveries in neurodegenerative diseases, like Parkinson’s and Alzheimer’s, and in other cell and disease biology fields. The new 8 mm 15N TROSY Cryoprobe provides twice the sensitivity of previous 5 mm detection, and 50% greater 13C sensitivity at 800 MHz.