Endometriosis

2022 - 12 - 23

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Image courtesy of "Medical Dialogues"

Tetramethylpyrazine: A promising drug candidate for treating ... (Medical Dialogues)

Endometriosis is a debilitating gynecologic disease affecting women of reproductive age; a major contributing cause of dysmenorrhea, chronic pelvic pain, ...

In summary, our study has shown that TMP treatment stalls lesional progression and fbrogenesis through suppression of platelet activation, platelet-induced EMT, FMT, cellular contractility, and collagen production. Our in vivo experiment demonstrates that treatment with TMP signifcantly reduced lesion weight and the extent of lesional fbrosis, and alleviated hyperalgesia. Their study showed that TMP treatment stalls lesional progression and fbrogenesis through suppression of platelet activation, platelet-induced EMT, FMT, cellular contractility, and collagen production. Based on linear regression analysis using the concentration of TMP as the co-variable, study found that, consistently, treatment with L-TMP and H-TMP concentration-dependently suppressed platelet-induced activation of TGF-β1, vimentin and fbronectin in endometriotic epithelial cells (all p values<0.030). "Our data strongly suggest that TMP is a compound with promising therapeutic potential for treating endometriosis. In endometriosis, in particular, it has been shown that, as one major ingredient in a concocted herbal formula, TMP suppresses lesional growth, infammation, and epithelial-mesenchymal transition (EMT) and induces apoptosis.

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Image courtesy of "Verywell Health"

Endo Belly: How to Find Stomach and Bloating Relief (Verywell Health)

In addition to painful periods, back, bladder, and hip pain, endo belly is another symptom that can be distressing. These therapies may offer relief.

[World endometriosis society consensus on the classification of endometriosis](https://doi.org/10.1093/humrep/dew293). [Associations between endometriosis and gut microbiota](https://doi.org/10.1007/s43032-021-00506-5). [Endometriosis in patients with irritable bowel syndrome: specific symptomatic and demographic profile, and response to the low FODMAP diet](https://doi.org/10.1111/ajo.12594). [An international terminology for endometriosis, 2021†,‡](https://doi.org/ doi:10.1093/hropen/hoab029). [Inflammatory mediators and pain in endometriosis: a systematic review](https://doi.org/10.3390/biomedicines9010054). [Association between atypical endometriosis and ovarian malignancies in the real world](https://doi.org/10.1186/s13048-021-00865-2). [Abdominal bloating: an under-recognized endometriosis symptom](https://doi.org/10.1016/s1701-2163%2816%2934377-8). [Gastrointestinal symptoms among endometriosis patients—a case-cohort study](https://doi.org/10.1186/s12905-015-0213-2). doi:10.1016/s1701-2163(16)34377-8 For example, one study found that 72% of people with endometriosis had a greater than 50% improvement in bowel symptoms, including [bloating](https://www.verywellhealth.com/abdominal-bloating-3496072), after four weeks of the [low FODMAP diet](https://www.verywellhealth.com/how-to-follow-the-low-fodmap-diet-1944680).10 2009;31(12):1159-1171. Endometriosis lesions are cut out (removed) and sent to pathology to confirm an endometriosis diagnosis.

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Image courtesy of "Endometriosis Foundation of America - The Blossom"

ENDOMETRIOSIS RESEARCH SUPPORT BILL SIGNED INTO LAW (Endometriosis Foundation of America - The Blossom)

Endometriosis research priorities passed by Congress and sent to the President included in final FY23 Consolidated Appropriations Act.

To think there is no cure is a hard reality to cope with, however, thanks to the committed and insightful legislators they are giving the 1 in 10 with endometriosis hope for a better tomorrow with funding for research to improve treatment options and a potential cure. [Tracey Haas](/-/tracey-haas) DO, Executive Director of EndoFound stated, “For the millions of women who suffer from Endometriosis that we work on behalf of everyday at the foundation, I want to offer our appreciation to Congress and our champions in the Congressional Endometriosis Caucus along with Sens. EndoFound looks forward to continuing to work with the Congressional Endometriosis Caucus, Senate champions, and the Biden Administration to prioritize research and awareness in the next fiscal year. Nikema Williams, David Scott, Kathleen Rice, and Jenniffer González-Colón of the Congressional Endometriosis Caucus to Senators Elizabeth Warren and Mitt Romney for all their hard work and for recognizing this is a bi-partisan issue that affects too many Americans. This legislation includes funding for the primary federal programs that support research into Endometriosis causes, treatments and potential cures - the National Institutes of Health’s National Institute of Child Health and Human Development (NICHD) and the Department of Defense’s Peer-Reviewed Medical Research Program (PRMRP). We applaud the House and Senate Labor, Health and Human Services, Education and Related Agencies Appropriations Subcommittees which prioritized Endometriosis research at both NICHD and PRMRP in the final legislation.

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