Endometriosis

2023 - 1 - 9

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Image courtesy of "The Guardian"

Scientists map cellular changes linked to endometriosis (The Guardian)

Treatment for endometriosis is currently limited to surgical removal of cysts and lesions, pain relief, and hormone therapies, such as the contraceptive pill or ...

The hope is that a better understanding of the molecular underpinnings of the disease will enable the development of more targeted therapies, as it has for cancer. This resource can now be used by researchers all throughout the world to study specific cell types that they specialise in, which will hopefully lead to more efficient and effective diagnosis and treatment for endometriosis patients. “We were able to identify the molecular differences between the major subtypes of endometriosis, including peritoneal disease [affecting the abdominal cavity] and ovarian endometrioma. To better understand the disease, Lawrenson and her colleagues analysed more than 400,000 cells from 21 patients, some of whom had endometriosis and others who were disease-free. Patients with the disorder can experience chronic pain, infertility, headaches and fatigue, as well as bowel and bladder dysfunction. But why does endometriosis behave like cancer while rarely becoming cancer?”

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Image courtesy of "New Scientist"

Genetic map of cells that cause endometriosis could improve ... (New Scientist)

Mapping the cells involved in endometriosis could improve our understanding of how genetics influences the risk of the condition and open the door to new ...

The map led to the team identifying a genetic mutation whose cellular effects could one day be an endometriosis drug target. However, the endometriosis map is inconclusive given the study’s small sample size, she says. It occurs when tissue similar to the lining of the uterus grows in other parts of the body, such as the ovaries, fallopian tubes and the tissue lining the pelvis. The remaining four women had not been diagnosed with endometriosis and acted as the control group. Of these women, 17 had been diagnosed with endometriosis, with some cells being taken from their endometriosis-related lesions. Endometriosis affects around one in 10 women worldwide, according to the World Health Organization.

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Image courtesy of "Nature.com"

Single-cell transcriptomic analysis of endometriosis - Nature Genetics (Nature.com)

Endometriosis is a common condition in women that causes chronic pain and infertility and is associated with an elevated risk of ovarian cancer.

Springer Nature or its licensor (e.g. [Methods](/articles/s41588-022-01254-1#Sec11) and panel (g). 705647, to D.G.H.) and a Canadian Institutes of Health Research Foundation grant (to D.G.H.). Cell Syst. Scrublet: computational identification of cell doublets in single-cell transcriptomic data. J. & Li, J. & Donnez, O. D. S., Mastellos, D. Cancer Res. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.

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Image courtesy of "SciTechDaily"

Improving Endometriosis Treatment Options: A Vast Cellular Atlas Is ... (SciTechDaily)

Researchers at Cedars-Sinai have developed a specific and comprehensive molecular profile of endometriosis to enhance treatment options for the many women ...

We expect it can do the same for endometriosis,” said Lawrenson, co-director of the Women’s Cancer Research Program at Cedars-Sinai Cancer. “Identifying these cellular differences at such a detailed level should allow us to better understand the origins, natural progression, and potential therapeutic targets for treatment. “The disease can travel throughout the body, so in many ways it behaves like cancer. “We generated a cellular atlas of endometriosis after analyzing nearly 400,000 individual cells from these patients. “Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. The disease impacts about 10% of women, usually during their reproductive years.

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Image courtesy of "Journal of Minimally Invasive Gynecology"

Endometriosis-related non traumatic diaphragmatic rupture with ... (Journal of Minimally Invasive Gynecology)

We describe the case of a 40-year-old woman with a previous diagnosis of diaphragmatic endometriosis non responsive to medical hormone therapy with ...

Ethical approval: IRB approval was not required. Gianmarco D'Ancona and Ludovica Verrelli have nothing to disclose. [Claim online access](/action/activateClaim) [Create an account](/action/registration?redirectUri=%2Farticle%2FS1553-4650%2823%2900001-8%2Ffulltext) [Sign in to ScienceDirect](https://www.sciencedirect.com/user/institution/login?targetUrl=/science/article/pii/S1553465023000018)

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Image courtesy of "REVYUH.com"

Endometriosis Secrets Unveiled: New Study Could Benefit Millions ... (REVYUH.com)

Endometriosis occurs when cells similar to those that line the uterus, called endometrial tissue, grow in abnormal locations, such as the ovaries,

We expect it can do the same for endometriosis,” adds Lawrenson. Using the new cellular map of endometriosis, researchers at Cedars-Sinai have already started testing treatment targets in a mouse model of the disease. “The disease can travel throughout the body, so in many ways it behaves like cancer.

Mapping endometriosis: A vast cellular atlas is created: Cedars ... (Science Daily)

Investigators have created a unique and detailed molecular profile of endometriosis to help improve therapeutic options for the millions of women suffering ...

We expect it can do the same for endometriosis," said Lawrenson, co-director of the Women's Cancer Research Program at Cedars-Sinai Cancer. "Identifying these cellular differences at such a detailed level should allow us to better understand the origins, natural progression, and potential therapeutic targets for treatment. "The disease can travel throughout the body, so in many ways it behaves like cancer. "Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. "We generated a cellular atlas of endometriosis after analyzing nearly 400,000 individual cells from these patients. The disease impacts about 10% of women, usually during their reproductive years.

Post cover
Image courtesy of "New Scientist"

Genetic map of cells linked to endometriosis could improve treatments (New Scientist)

Mapping the cells involved in endometriosis could improve our understanding of how genetics influences the risk of the condition and open the door to new ...

The map led to the team identifying a genetic mutation whose cellular effects could one day be an endometriosis drug target. However, the endometriosis map is inconclusive given the study’s small sample size, she says. It occurs when tissue similar to the lining of the uterus grows in other parts of the body, such as the ovaries, fallopian tubes and the tissue lining the pelvis. The remaining four women had not been diagnosed with endometriosis and acted as the control group. Of these women, 17 had been diagnosed with endometriosis, with some cells being taken from their endometriosis-related lesions. Endometriosis affects around one in 10 women worldwide, according to the World Health Organization.

Post cover
Image courtesy of "News-Medical.net"

Detailed molecular profile of endometriosis can lead to improved ... (News-Medical.net)

The disease impacts about 10% of women, usually during their reproductive years. Patients with the disorder can experience chronic pain, infertility, headaches, ...

We expect it can do the same for endometriosis," said Lawrenson, co-director of the Women's Cancer Research Program at Cedars-Sinai Cancer. "The disease can travel throughout the body, so in many ways it behaves like cancer. Identifying these cellular differences at such a detailed level should allow us to better understand the origins, natural progression, and potential therapeutic targets for treatment. "Endometriosis has been an understudied disease in part because of limited cellular data that has hindered the development of effective treatments. "We generated a cellular atlas of endometriosis after analyzing nearly 400,000 individual cells from these patients. The disease impacts about 10% of women, usually during their reproductive years.

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